Active Clinical Trials Using Adipose-Derived MSCs: A 2026 Physician Reference
The clinical case for banking autologous adipose tissue rests on a research pipeline, and that pipeline is best understood from primary sources rather than summaries. As of 2026, active trials are studying adipose-derived mesenchymal stem cells across several condition categories, from neurodegenerative disease to musculoskeletal and inflammatory conditions. What follows is a physician reference to […]
Adipose-Derived Stem Cells in Autoimmune and Inflammatory Conditions: What the Evidence Shows
The December 2024 FDA approval of Ryoncil for steroid-refractory acute graft-versus-host disease was not an orthopedic milestone. It was an immune milestone, confirming that the FDA will approve mesenchymal stem cell-based therapies for immune and inflammatory conditions when the Phase 3 evidence supports them. Adipose-derived stem cells share the same core immunomodulatory properties that drove […]
Expanded Access Programs for Investigational Drugs: What Physicians and Patients Need to Know
Expanded access, also called compassionate use, is the FDA pathway that allows patients with serious or life-threatening conditions to access investigational drugs, biologics, or medical devices outside of a clinical trial when no comparable alternative therapy is available. The process requires the treating physician to submit a request to the FDA and obtain agreement from […]
MFAT Injections: What They Are, What the Evidence Shows, and How They Relate to Banking
MFAT, micro-fragmented adipose tissue, is a preparation of mechanically processed fat tissue that retains an intact stromal vascular niche, including adipose-derived stem cells, pericytes, and extracellular matrix components, and is injected at the site of injury or disease. Multiple clinical trials have evaluated MFAT injections for orthopedic applications, particularly knee osteoarthritis, with published data demonstrating […]
Adipose-Derived Stem Cells in Kidney, Heart, and Lung Disease: What Organ Trials Are Actually Showing
Adipose-derived stem cells and their secreted factors are being studied across multiple organ systems because they appear to modulate inflammation, reduce scarring, and support cell survival in animal models of chronic organ disease. Patients with kidney, heart, or lung conditions now encounter headlines about fat stem cell trials and case reports and want to understand […]
Adipose-Derived Stem Cells in Neurology: Stroke, Spinal Cord Injury, ALS, and Brain Disorders
Adipose-derived stem cells have attracted growing attention in neurology because they secrete growth factors that support damaged tissue, modulate inflammation, and appear to influence recovery in animal models of several serious neurologic conditions. Researchers are now testing whether these properties can translate into clinical benefit in conditions like ischemic stroke, spinal cord injury, ALS, and […]
How Adipose-Derived Stem Cells Modulate the Immune System (And What That Means for Future Therapies)
Adipose-derived stem cells are not just building blocks for new tissue. They also communicate actively with the immune system, releasing signaling molecules and interacting directly with immune cells in ways that researchers are still working to characterize. Scientists are exploring whether this immune modulation could eventually be useful in certain inflammatory and immune-mediated diseases, but […]
Adipose-Derived Stem Cells in Wound Healing Research: A Deeper Look at Published Trials
Chronic wounds are one of the most persistent and difficult challenges in medicine. Diabetic foot ulcers, pressure ulcers, and ischemic limb wounds affect millions of people and often fail to heal even with best-practice wound care. Researchers are now testing whether adipose-derived stem and stromal cells might support healing in these conditions, and a growing […]
Adipose-Derived Stem Cells in Cardiovascular Research: What Trials Are Currently Registered
Researchers are studying whether adipose-derived cells might one day contribute to the treatment of certain cardiovascular conditions, but this work is still in the research phase and no products have been approved. If you have seen headlines about “fat stem cells healing the heart” and wondered whether those stories reflect real science or marketing, this […]
What Informed Consent Means in Regenerative Medicine Research
Informed consent is a process, not a signature on a form. It is the foundation of ethical research involving human beings, and it exists to ensure that every person who participates in a clinical study does so with a clear understanding of what the study involves, what the risks are, and that their participation is […]